The probe used in this dataset recognizes the PKM transcript which is preferentially spliced in GBM to yield the PKM2 isoform.11 High (upper 10th percentile) PKM expression was significantly prognostic of reduced overall survival in patients that received genotoxic treatment (log rank P = 0.006; Fig. 1f) but not in those patients that did not receive genotoxic treatment (log rank P = 0.09; Supplementary information, Fig. S1g), suggesting an important clinical role of PKM2 in genotoxic treatment resistance. Here, PKM is linked to glioblastoma.