PKM and glioblastoma: Like actual human GBM tumors (Supplementary information, Fig. S1e), the mouse intracranial U87/EGFRvIII tumor model exhibits rapid proliferation as evidenced by Ki-67 staining (Fig. 1d) and expresses high levels of PKM2 and little PKM1 while, conversely, the surrounding normal brain tissue expresses high levels of PKM1 and little PKM2 (Supplementary information, Fig. S1f).