Increased sensitivity to radiation following PKM2 knockdown was confirmed by transient knockdown of PKM2 in U87, T98G, and U251 GBM cell lines (Fig. 1b, Supplementary information, Fig. S1b and c), as well as in H1299 (non-small cell lung cancer; data not shown) and HT1904 (derived from the HT1080 fibrosarcoma line; data not shown). This evidence concerns the gene PKM and glioblastoma.