Taken together, the data identified the human Caco-2, MCF-7 and OE-33 cells as well as the canine TiHoDMglCarc1305 cells, expressing claudin-3, -4 and -7, as good candidates to test whether claudin expressing tumor cells can be specifically targeted using GNOME-LP technique in combination with the C-CPE-AuNP complex. The gene discussed is CLDN3; the disease is neoplasm.