The present report shows that C-CPE coupled to Strep-Tactin conjugated gold nanoparticles (C-CPE-AuNP) can be combined with the gold nanoparticle-mediated laser perforation (GNOME-LP) technique32 for a specific targeting of claudin-3, -4 and 7 expressing tumor cells (Figs 1, 4 and 5). Here, CLDN3 is linked to neoplasm.