NOTCH1 and medulloblastoma: Mice injected with doxycycline-treated, and hence decreased NOTCH1 expressing, medulloblastoma cells (shNotch1 + Dox, Fig. 2a–c and Supplementary Fig. 7a, b) presented lower frequency of spinal metastases compared with control cells (shNotch1−Dox, Fig. 2a-c and Supplementary Fig. 7a, b).