Interestingly, TWIST1-silenced medulloblastoma cells present similar levels of MYC expression as compared with control, suggesting that NOTCH1, but not TWIST1, is upstream of MYC. This finding indicates that NOTCH1–MYC and NOTCH1–TWIST1–BMI1 act at different axes in Group 3 medulloblastoma metastasis. The gene discussed is MYC; the disease is medulloblastoma.