Our data from in vivo spontaneous metastasis across five Group 3 human medulloblastoma lines, a MYC-driven mouse medulloblastoma cell line, and from human medulloblastoma gene expression database analysis, show that medulloblastoma spinal metastases present higher NOTCH1 pathway expression than matched primary tumors and that NOTCH1 pathway activation increases medulloblastoma metastasis and reduces survival. Here, MYC is linked to medulloblastoma.