Accordingly, in this study we aimed to: (1) analyze systematically the expression of different components of ghrelin system in gastroenteropancreatic-(GEP-)NETs compared to non-tumor adjacent (NTA) tissue and, most importantly, to normal control tissues by quantitative real-time PCR (qPCR); (2) correlate the expression of these components with clinical/histological characteristics; and (3) perform in vitro experiments to elucidate the potential pathophysiological role of GOAT enzyme as a key component particularly altered in our cohort of NET samples, using BON-1 and QGP-1 cell lines. The gene discussed is GHRL; the disease is neoplasm.