Among the 12 pathways, Cell cycle, TSC/mTOR and Hormone receptor signaling pathways showed the most significant levels of cross-signaling across cancer types- Hormone receptor pathway showed significance across 13 cancer sites including kidney cancer (KIRC), lung cancers (LUAD, LUSC), CORE, PAAD, STAD, LIHC, MESO, UCS, OV, LGG, ESCA, and DLBC. This evidence concerns the gene NR4A1 and kidney cancer.