We investigated 12 pathways of critical importance to the behavior of tumor cells and response to therapy: apoptosis, breast reactive, cell cycle, core reactive, DNA damage response, EMT, PI3K/AKT, RAS/MAPK, RTK, TSC/mTOR, hormone receptor, and hormone signaling (breast) as described in the previous TCGA RPPA study for 11 tumor types22. This evidence concerns the gene AKT1 and neoplasm.