MTOR and cancer: Among the 12 pathways, Cell cycle, TSC/mTOR and Hormone receptor signaling pathways showed the most significant levels of cross-signaling across cancer types- Hormone receptor pathway showed significance across 13 cancer sites including kidney cancer (KIRC), lung cancers (LUAD, LUSC), CORE, PAAD, STAD, LIHC, MESO, UCS, OV, LGG, ESCA, and DLBC.