Higher levels of this cytokine were found in patients with multiple sclerosis, rheumatoid arthritis, and Crohn’s disease.35 Interestingly, allergic sensitivity to atopic dermatitis was positively correlated with serum levels of IL-16, as well as total IgE,36,37 although the correlation with IL-16 was weaker than the correlation with IgE levels. This evidence concerns the gene IGHE and Crohn disease.