Furthermore, the activation of C- and Aδ-fibers by injecting capsaicin (a transient receptor potential vanilloid 1 (TRPV1) agonist) or mustard oil (a TRP ankyrin 1 (TRPA1) agonist) into skin with neurogenic inflammation over the median nerve blocks the development of hypertension in rats31. The gene discussed is TRPA1; the disease is hypertensive disorder.