ACHE and Alzheimer disease: Despite the fact that research has discovered some of biological goals targets against AD which includes acetylcholinesterase (AChE), N-methyl-d-aspartate (NMDA) receptor, glycogen synthase kinase 3 (GSK3), cyclin-dependent kinase 5 (CDK5), secretase, etc. but the specific drug molecules against these targets showing a complete cure of the disease stay unknown1,2.