In addition, to relate the function of these selected proteins to their roles in the pathogenesis of hepatic steatosis and dysmorphic mitochondrial under conditions of hypercholesterolaemia, the expression of apoptotic protein (caspase-3), mitochondrial fission protein (DRP1), mitochondrial fusion protein (OPA1) and autopagic protein (LC3) was examined. The gene discussed is OPA1; the disease is Hepatic steatosis.