ANK3 and Behcet disease: Our results indicate that, at least with regards to ANK3’s role in the etiology of BD, the elevated expression of the alt-2 splice form is most likely occurring in oligodendrocytes and probably not in neurons, and its protein product may well be located at the nodes of Ranvier since an ANK3 isoform has been detected on the glial side of the paranodes (Fig. 1c)14.