A diagnostic model established with serglycin and six other peptides (α-fetoprotein, prothrombin, isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4, isoform 1 of autophagy-related protein 16-2, and transthyretin and fibrinogen beta chains) achieved a high recognition rate and predictive power for HCC patients with bone metastasis. This evidence concerns the gene SRGN and hepatocellular carcinoma.