There are lncRNAs in which the secondary structure dictates their functionality, in humans the lncRNA MEG3 acts as a tumor suppressor based in the structure rather than in the primary sequence conservation [83], also the steroid receptor RNA activator (SRA), one of the few lncRNA that has its secondary structure experimentally defined, is reported to interact with many proteins and be related to breast cancer development. Here, MEG3 is linked to breast carcinoma.