In subgroup analysis for patients without malignancy disease, the relative risk for mortality was also associated with APACHE II score (hazard ratio (HR) = 1.04, 95% CI = 1.03–1.06, p < 0.001) and CRP/albumin ratio (HR = 1.39, 95% CI = 1.02–1.90, p = 0.04 for high CRP/albumin ratio). The gene discussed is CRP; the disease is cancer.