Transglutaminase 2 is responsible for the change of normal physiology including fibroblast function [4], wound healing [5], clearance of apoptotic cells [6], macrophage phagocytosis [7], glucose tolerance [8] as well as playing a key role in the development of disease pathogenesis including various cancers [9,10,11], and several neurological disorders including Huntington’s, Alzheimer’s and Parkinson’s [12,13,14]. Here, TGM2 is linked to cancer.