This p53- TGase 2–p62 interaction of triple complex has an advantage of rapid autophagy to compare to mouse double-minute 2 homolog (MDM2) mediated p53 ubiquitination, which is directly destined to microtubule-associated protein light chain 3 (LC3) on the membrane of autophagosome through p62 binding in RCC [30]. The gene discussed is TP53; the disease is renal cell adenocarcinoma.