DDIT3 and central nervous system cancer: In glioblastoma, upregulation of TGase 2 expression by microglia-derived cytokines induces CCAAT-enhancer-binding protein β (C/EBPβ) expression by depleting DNA damage-inducible transcript 3 (GADD153), triggering mesenchymal transdifferentiation of glioma stem cells [61].