The transglutaminase 2 (TGase 2, E.C. 2.1.2.13) inhibitor GK921, 3-(phenylethynyl)-2-(2-(pyridin-2-yl)ethoxy)pyrido[2,3-b]pyrazine, eliminates renal cell cancer (RCC) in a xenograft model by inhibiting TGase 2 [25]. The gene discussed is TGM2; the disease is renal cell adenocarcinoma.