VHL and cancer: More reactions and biological functions of TGase 2 are discussed in the reviews [1,15] including nuclear factor κB (NF-κB) activation through NF-κB inhibitor α (I-κBα) inhibition [16], hypoxia-inducible factor 1α (HIF-1α) activation through von Hippel–Lindau tumor suppressor (VHL) inhibition [17] and suppression of apoptosis in cancer through p53 inhibition [15,18].