Regarding the role of RELMβ in the colon, changes in RELMβ-induced gut microbiota might be involved in the impairment of gut permeability and the induction of endotoxemia, since RELMβ KO mice showed a higher proportion of Lactobacillus, which reportedly contributes to the normalization of tight junction proteins and reduced endotoxemia [27,28,29]. This evidence concerns the gene RETNLB and serum lipopolysaccharide activity.