RYR2 and catecholaminergic polymorphic ventricular tachycardia: However, previously described CPVT-associated RyR2 mutants, including RyR2-G230C, RyR2-S2226L, RyR2-P2328S, RyR2-R2474S, RyR2-Q4201R, RyR2-R4497C, and RyR2-V4653F, are linked to a PKA-dependent phosphorylation of RyR2 channel activity during sympathoadrenergic stimulation [7–9].