KRT78 and posterior cortical atrophy: Although the KRT78 gene was upregulated (~ 25-fold) in both HEK293T and HAP1 when a 1.6-kb region encompassing PCa risk-associated CTCF site on chr12 was deleted (Additional file 1: Figure S3), deletion of a 2.8-kb region encompassing the PCa risk-associated CTCF site on chr1 in HEK293T or HAP1 cells did not result in an increase in KCNN3 expression (Additional file 1: Figure S4).