TMEM106B and frontotemporal dementia: Although the effects of deletion of other GWAS-related CTCF sites have not been reported, Gallager et al. have proposed that a CTCF site near a SNP involved in risk for frontotemporal lobar degeneration creates a loop that enhances expression of TMEM106B; however, because the CTCF site was not deleted, the actual effect of the site on gene expression is not known [38].