Perhaps the PCa risk-associated CTCF sites can establish repressive loops with other CTCF sites upon deletion of the other ends of the original loops; we note that there are several CTCF peaks with motifs oriented in the correct direction that could possibly be adopted as a new anchor for CTCF site 1 and site 4 if the normal loop anchor sites are deleted. Here, CTCF is linked to posterior cortical atrophy.