Large, rigorously conducted clinical trials using an SGLT2 inhibitor, such as empagliflozin for the EMPA-REG OUTCOME trial [4] and canagliflozin for the CANVAS Program, [5] found that patients with T2DM at high risk of cardiovascular events derived cardiovascular benefits from the SGLT2 inhibitor as compared with from a placebo. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.