NPPB and type 2 diabetes mellitus: No significant change was observed in BNP 6 months after administration of dapagliflozin from 27.9 pg/mL (9.0–58.2) at baseline to 28.9 pg/mL (9.6–62.9) (p = 0.132), but BNP significantly decreased from 168.8 pg/mL (144.3–465.3) to 114.3 pg/mL (98.3–235.3) (p = 0.012) in T2DM patients with BNP ≥ 100 pg/mL (Fig. 3).