In this study, we report the generation of hiPSCs from two individuals from the Arizona APOE Cohort (for which recruitment and enrolment strategies have been described previously (Caselli et al., 2011)) that are homozygous for the APOE e4 allele— a clinically diagnosed AD patient (ASUi005-A, Mini-Mental Status Exam [MMSE] score = Patient too advanced to collect data). This evidence concerns the gene APOE and Alzheimer disease.