PF4 and systemic sclerosis: In addition to participating in cardiovascular diseases[48], tumors[18], systemic sclerosis[17], pancreatitis[49] and hepatic fibrosis[50], CXCL4 plays important roles in lung inflammatory diseases, such as in acute lung injury[42], infection-induced lung injury[36] and lung cancer[51], by promoting platelet production and regulating neutrophil infiltration.