Although the seroprevalence of blood donors had been documented [14–16, 29–35], the impact of the IgM positive- or IgM/IgG dual positivity bloods on the transfusion transmission of DENV is largely unknown today despite it has been proposed that not only DENV but also anti-dengue antibodies may pose a risk to blood transfusion safety [36]. This evidence concerns the gene CD40LG and dengue disease.