SIRT1 and amyotrophic lateral sclerosis: Studies using resveratrol, a polyphenolic compound that activates SIRT1 and other targets, have shown mixed effects in the SOD1G93A mouse model of ALS, with some dosing regimens showing protection and others indicating no effect on disease progression (Han, Choi, Soon Shin, & Kang, 2012; Kim et al., 2007; Mancuso et al., 2014; Markert, Kim, Gifondorwa, Childers, & Milligan, 2010; Song, Chen, & Zhang, 2014).