Overexpressing PGC1α slows ALS‐related pathologies in SOD1G93A mice (Zhao et al., 2011), and more directly, elevating SIRT1 expression using the prion promoter has shown lifespan extension in the SOD1G93A low copy transgenic mouse line (Watanabe et al., 2014). The gene discussed is SIRT1; the disease is amyotrophic lateral sclerosis.