SIRT1 and amyotrophic lateral sclerosis: SIRT1 overexpression slowed disease progression in the high copy SOD1G93A model of ALS, and transcriptional analysis of spinal cord showed extensive overlap in transcriptional changes that occur centrally in the SOD1G93A model of ALS and during normal aging of wild‐type mice with a substantial upregulation of immune and inflammatory response genes.