CD274 and familial pancreatic carcinoma: Recent correlation of cytolytic immune activity with mutational, structural, and neoepitope features in human PDAC samples has identified potential genomic signatures predictive of low cytolytic T-cell activity and expression signatures for multiple immune checkpoints other than PD-1/PD-L1 predictive of high immune cytolytic activity that altogether provide impetus for further investigation into therapeutic strategies that target multiple other immune checkpoints in pancreatic cancer [80].