A German group isolated antigen-primed monocyte derived dendritic cells (DCs) from 44 patients with stage IV pancreatic cancer who failed first-line chemotherapy and demonstrated a median OS of 8 months with DC vaccine alone; however combination DC vaccine and PD-L1 blockade was able to induce secondary stabilization of disease of 4–8 months in 5/10 patients who failed to respond to previous DC therapy [46]. Here, CD274 is linked to familial pancreatic carcinoma.