CD274 and familial pancreatic carcinoma: Although limited by a small sample size of 5 patients with pretreated advanced pancreatic cancer, treatment with a bifunctional anti-PD-L1 and TGFβ receptor II fusion protein was efficacious and well-tolerated with a MTD not reached at the highest dose, altogether highlighting the feasibility of multitargeted fusion constructs involving checkpoint blockade [58].