A pilot phase I study demonstrated a PR in 1 patient with mismatch repair (MMR) deficiency out of 5 patients with pretreated advanced pancreatic cancer using a bifunctional fusion protein of anti-PD-L1 antibody fused to the extracellular domain of TGFβ receptor II (TGFβ trap) [58]. The gene discussed is CD274; the disease is familial pancreatic carcinoma.