MTOR and angiomyolipoma: For angiomyolipomas larger than 3 cm in diameter, recommendations indicate that the first-line therapy should be a mechanistic target of rapamycin (mTOR inhibitor) [20], a protein that in humans is encoded by the mTOR gene regulating cell growth, proliferation, cell motility, cell survival, protein synthesis, autophagy and transcription, and an inhibitor to prevent continued growth and bleeding [22].