Our experience includes the treatment of a patient with adenosine deaminase deficiency with erythrocyte encapsulated adenosine deaminase and the administration of EETP to five patients with MNGIE under a compassionate use program.5, 6, 14, 15, 16, 17 A recombinant E. coli source of GMP TP has been developed to support a clinical trial of EETP. This evidence concerns the gene ADA and hyperinsulinemic hypoglycemia, familial, 4.