We hypothesize that HemR1 and HemR2 together with HemTUV-1, a periplasmic/inner membrane ABC heme transporter also encoded by the hem-1 locus, may constitute a system involved in the acquisition of the heme moiety from host hemoproteins under the varied conditions encountered by Y. enterocolitica during an infection. This evidence concerns the gene ABCB6 and infection.