PIWIL2 and neoplasm: However, it has been demonstrated to be temporarily activated in somatic cells in response to DNA damages (Lim et al., 2013) Furthermore, PIWI-LIKE 2 reveals ectopic expression in several tumor entities, and its intragenically activated products, such as PL2L60A, are expressed in various types of tumor cell lines (Ye et al., 2010; Gainetdinov et al., 2014).