Consistent with the frequent amplification of TRAF2 detected in human epithelial cancers (Figure 1B) (103), TRAF2 expression is higher in prostate cancer (133), pancreatic cancer (132), lung cancer (134), stomach cancer (135), colon cancer (136), glioblastoma (137) than in normal tissues. Here, TRAF2 is linked to familial pancreatic carcinoma.