There are five different fusions of the TRAF2 gene detected in human cancers, including TRAF2-CCDC183 in breast and bladder cancers, TRAF2-CACNA1B in bladder cancer, TMEM141-TRAF2 in breast cancer (TCGA), TRAF2-NOTCH1 in ovarian cancer (106) and NTRK2-TRAF2 in melanoma (115). The gene discussed is NOTCH1; the disease is urinary bladder cancer.