Subanalysis according to BMI categories (normal-weight, BMI 18.5–24.9 kg/m2; overweight, BMI 25.0–29.9 kg/m2; obesity, BMI 30.0–40.0 kg/m2) did not show evidence for a mediator role of CRP (Table 4). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.