On top of demonstrating the beneficial effects of yoga intervention on alleviating central obesity and improving physical performance, we investigated the effects of 1-year yoga training on β-cell function, insulin resistance, and metabolism-related peptides, including GH, insulin, and ghrelin gene products namely UnAG, AG, total ghrelin, and obestatin, in MetS adults with central obesity. The gene discussed is GHRL; the disease is Insulin resistance.