IL-1 induces anorexia associated with reduced food intake by acting in the hypothalamic nuclei of the CNS, where it inhibits the orexigenic factor Neuropeptide Y and indirectly increases the corticotropin releasing factor (CRF) levels (Patra and Arora, 2012); additionally, it stimulates CRF and somatostatin secretion, mediated by prostaglandin E2 (PGE2) (Gautron and Layé, 2010). This evidence concerns the gene CRH and Anorexia.