In this regard, a randomized clinical trial (Daneryd et al., 1998) in 108 cancer patients with advanced tumors at different sites with cachexia not undergoing concomitant chemotherapy showed that the administration of rHuEPO in association with the anti-inflammatory agent indomethacin achieved a higher increase in Hb levels as well as increased oxygen uptake, and respiratory activity with a better-preserved exercise capacity in comparison to the arm with indomethacin alone. This evidence concerns the gene GSTM1 and cancer.