In a meta-analysis of patients treated with Nivolumab, Pembrolizumab or MPDL3280A (an engineered anti-PD-L1 antibody), response rates are significantly higher in PD-L1-positive tumors, and the predictive role of PD-L1 on tumor cells is stronger for Pembrolizumab and Nivolumab (Carbognin et al., 2015). Here, CD274 is linked to neoplasm.