Tumor-intrinsic activation of WNT/β-catenin signaling pathway results in subdued CCL4 expression and subsequent precluded dendritic cell (DC) recruitment and DC-mediated T-cell activities, thus leading to resistance to anti-PD-L1 and anti-CTLA-4 therapies (Spranger et al., 2015). This evidence concerns the gene CTLA4 and neoplasm.