PBRM1 and renal cell carcinoma: Interestingly, studies adopting the same approach newly discover that the loss-of-function mutations in PBRM1, which encodes a subunit of a SWI/SNF chromatin remodeling complex (the PBAF subtype), might improve the responsiveness to ICBs due to activation of JAK-STAT signaling pathway and elevated sensitivity to IFNγ in renal cell carcinoma (RCC) and melanoma, respectively.