SIGMAR1 and amyotrophic lateral sclerosis: Meanwhile, administration of the Sig-1R agonist PRE-084 was shown to slow the progression of ALS in SOD1*G93A mouse ALS model and significantly reduced microglial marker Iba1-1 immunoreactivity in the spinal cord, but did not affect astroglial reactivity (Mancuso et al., 2012).