SIGMAR1 and stroke disorder: Recently, it was shown that treatment with Sig-1R agonist PRE-084 at 3 h and 24 h after the embolic stroke onset significantly reduced infarct volumes and improved neurological deficits by inhibiting pro-inflammatory cytokines and enhancing anti-inflammatory cytokines, such as IL-10 and IL-4 following cerebral ischemia (Allahtavakoli and Jarrott, 2011).