It has been reported that Andro could reduce the expression of NADPH oxidase 2 (NOX2), as well as inducible-nitric oxide synthase (iNOS), and it protect against cerebral ischemia via attenuating nuclear factor kappa B (NF-κB) and inhibiting the expression of hypoxia-inducible factor 1-α (HIF-1α) (Lu et al., 2006; Chern et al., 2011). Here, NOS2 is linked to brain ischemia.