We have experimentally validated a group of oncomiRs (miR-503-5p, miR-450b-5p, miR-27a-3p, miR-181a-5p and miR-183-5p) in repressing the expression of RORA, which is proven to be a major tumor suppressor by clinic sample analysis, as well as by cell proliferation and nude mice assays. This evidence concerns the gene RORA and neoplasm.