TNFRSF8 and anaplastic large cell lymphoma: In general, chromosomal translocation of the ALK gene was observed in 50%–85% of ALCL patients,104 and the knockout of ALK gene significantly increased the death rate of ALCL cells.105, 106 The in vitro studies revealed that the nanocomplex selectively bound to CD30(+) ALCL cells, effectively silenced cell ALK oncogene, and triggered growth arrest as well as apoptosis of ALCL cells Karpas 299.103