Essentially, it enhances maturation, survival proliferation, and maintenance of peripheral B cells by interacting with its ligand B cell-activating factor (BAFF).126, 127 Overexpression of BAFF-R is found in several types of B cell lymphomas,128 including the most common type of diffuse large B cell lymphoma (DLBCL)129 and a rare, aggressive type of mantle cell lymphoma.130. The gene discussed is TNFRSF13C; the disease is diffuse large B-cell lymphoma.