APP and frontotemporal dementia: Another theoretical explanation for the more pronounced decrease of Aβ-38 in FTD could be γ-secretase modulation; decreased processivity of APP by γ-secretase could result in lower concentrations of shorter Aβ peptides, such as Aβ38 (Chavez-Gutierrez et al., 2012), but this has to the best of our knowledge not been studied in FTD.