LH/FSH ratio was significantly higher in PCOS-IR women (1.67 ± 1.75) compared to controls (0.94 ± 0.68, P=0.047) but not significantly different from that of PCOS-IS group (1.45 ± 0.94) (Fig .1). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.