IL-22 was found to be crucial in cutaneous immunity against staphylococcal infection first through the induction of adenosine monophosphates (AMPs) (Mulcahy et al. 2016; Wolk et al. 2006) synthesis and second by influencing T-cell and neutrophil chemotaxis (Chan et al. 2015). Here, IL22 is linked to staphylococcal infection.