One of our most striking experimental results was the high glucose-induced hypertrophic change in hiPSC-derived cardiomyocytes with increased cell size, associated with increased SGLT1, SGLT2 and NPPB expression that was exhibited by marked hypertrophic changes with increase in cell size, and increased NPPB and SGLT1 expression resembling that seen in human diabetic cardiomyopathy. The gene discussed is SLC5A2; the disease is diabetic cardiomyopathy.