Thus, our observation of increased Ucp-3 expression in eWAT of Ogg1Tg mice (Fig. 4i) is consistent with their increased proton leak (Fig. 4e) and higher expression of fat oxidation genes (Fig. 3a), as well as with their resistance to diet-induced obesity (Fig. 1). This evidence concerns the gene UCP3 and obesity due to melanocortin 4 receptor deficiency.