TNF and infectious disease: Interestingly, NF-κB dependent transcripts such as serum amyloid A (saa) and NF-κB inhibitor alpha a (nfkbiaa)10 and inflammatory cytokines such as il1b, tnfa, and il6, characteristic of TLR-stimulated Myd88-dependent signaling in infectious disease, did not exhibit significant transcriptional regulation (Fig. 2a).