As shown in Fig. 7e–g, the secretion of IL-1β and IL-18 was also inhibited in glyburide-treated T2D mice, indicating that the activation of NLRP3 inflammasome was inhibited by glyburide in vivo, although glyburide didn’t directly inhibit NLRP3 protein23. Here, IL18 is linked to type 2 diabetes mellitus.