CLANmCas9/gNLRP3 was unable to entirely prevent septic shock and peritonitis likely because of the activation of other inflammasomes, such as NLRP1, NLRC4, and AIM23,5,7, and the inactivation of the NLRP3 inflammasome was insufficient to inhibit acute inflammation. The gene discussed is NLRP1; the disease is peritonitis.