This dose response is also reflected in the fully adjusted models in Table 2; compared to women living in areas with low residential road traffic noise levels (< 48 dB), the highest HRs were observed in the fully adjusted models for women exposed to the highest noise levels (> 58 dB) (HR; 95% CI, 1.30; 1.07–1.60 in 1193 of all BC cases and 1.42; 1.06–1.89 in 611 BC cases with full ER and PR hormone receptor status); and smaller HRs in women exposed to medium noise levels (48–58 dB) (HR; 95% CI: 1.24; 1.04–1.47 in 1193 cases and 1.28; 0.99–1.65 in 611 cases). The gene discussed is ESR1; the disease is breast cancer.