ALX3 and neural tube defect: Embryos from vitamin E supplemented females showed higher mRNA levels for Alx3 and Neurog2 in WT (WT + VE) and morphologically normal SR-B1 KO (KO + VE) embryos, reaching levels over control values (Fig. 2c) and suggesting that changes in the expression of neural tube-related genes may contribute to the preventive effect of α-tocopherol on NTD.