IGFBP3 and acromegaly: When comparing the patients of each subgroup with controls, we found a significant association between IGFBP3 genotype and a reduced acromegaly risk in the GH-secreting macroadenoma group (OR 0.557, 95% CI 0.347–0.893) and the monotherapy group (OR 0.512, 95% CI 0.316–0.828) under the additive model.