DEFB1 and preterm premature rupture of the membranes: A heterozygous nonsense variant (rs5743490) of African ancestry in the Defensin Beta 1 (DEFB1) gene, which encodes a small cysteine-rich cationic peptide that damages the cellular membranes of bacteria and some viruses, was found in PPROM cases in our initial WES and targeted genotyping [9], but not in neonates born at term (Tables 1, 2, 3 and 4).