NXPH1 and type 1 diabetes mellitus: SNP rs110361335 on BTA4 is located within an intron of the islet cell autoantigen 1 (ICA1) gene, which is known to be associated with glucose regulation and type 1 diabetes in humans [54], while SNP rs110564527 is located in the region near the candidate gene neurexophilin 1 (NXPH1), which has no known association or characterization in cattle.