For the elder patients diagnosed with KOA, they were more likely to select TKR as their method of treatment.[22] DVT and PE are fatal perioperative complications after TKR.[23] Selective inhibition of the factor Xa, such as rivaroxaban, could prevent, as well as process DVT, but the risk of wound complications and knee swelling increases with the use of rivaroxaban.[24,25] Therefore, in this present study, we investigated the effects of rivaroxaban on both the hidden blood loss and BTR following TKR. This evidence concerns the gene F10 and deep vein thrombosis.