In addition, aniridia is associated with several non-ocular conditions such as obesity, glucose intolerance and diabetes, and anosmia.3, 4 These conditions are due to a requirement for PAX6 expression for the development and maintenance of the brain, pancreas, and gut.5, 6, 7 The progressive nature of the disease reflects an ongoing requirement for PAX6 expression and suggests there may be an opportunity for therapeutic intervention postnatally. Here, PAX6 is linked to Glucose intolerance.