PAX6 and isolated aniridia: miR-7 and miR-375 are expressed in the pancreas and have been shown previously to regulate PAX6.20, 21, 22, 23, 24 Given the pancreatic involvement in aniridic patients, these miRNAs targeting PAX6 provided an opportunity to address the question of whether targeting miRNA regulation of PAX6 is feasible therapeutic strategy for aniridia.