We first showed by miRNA overexpression, miR-7 and miR-375 reporters, Pax6 3′ UTR reporters, and Tud inhibitors of miR-7 and miR-375, that miR-7 and miR-375 regulate PAX6 protein levels within the β-TC-6 insulinoma cell line. The gene discussed is PAX6; the disease is pancreatic insulinoma.